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GSE48303
Homo sapiens
13 Downloadable Samples
Affymetrix Human Gene 1.0 ST Array (hugene10st)
Description
Analysis of aldosterone-producing adenoma (APA) samples from patients with primary hyperaldosteronism. These APAs have a somatic mutation in either KCNJ5, CACNA1D, or ATP1A1. Results provide insight into the different mechanisms each mutation may cause leading to elevated aldosterone production in APA.
Publication Title
Somatic mutations in ATP1A1 and CACNA1D underlie a common subtype of adrenal hypertension.
Sample Metadata Fields
Specimen part, Disease, Disease stage
View Samples- Homo sapiens
- 332 Downloadable Samples
- Illumina HumanHT-12 V4.0 expression beadchip
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
Host Transcription Profile in Nasal Epithelium and Whole Blood of Hospitalized Children Under 2 Years of Age With Respiratory Syncytial Virus Infection.
Sample Metadata Fields
Sex, Age, Specimen part, Disease, Disease stage
View Samples- Homo sapiens
- 166 Downloadable Samples
- Illumina HumanHT-12 V4.0 expression beadchip
Description
Analysis of transcriptional profiles in whole blood and nasopharyngeal swaps from children hospitalized with lower respiratory tract infections at their admission and their discharge, and diagnosed with either RSV or rhinovirus infections.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part, Disease stage
View Samples- Homo sapiens
- 166 Downloadable Samples
- Illumina HumanHT-12 V4.0 expression beadchip
Description
Analysis of transcriptional profiles in whole blood and nasopharyngeal swaps from children hospitalized with lower respiratory tract infections at their admission and their discharge, and diagnosed with either RSV or rhinovirus infections.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Disease, Disease stage
View Samples- Homo sapiens
- 22 Downloadable Samples
- Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)
Description
Although host genetics influences susceptibility to tuberculosis, few genes determining disease outcome have been identified. We hypothesized that macrophages from individuals with different clinical manifestations of tuberculosis infection would have distinct gene expression profiles, and that polymorphisms in these genes may also be associated with susceptibility to TB.
Publication Title
Identification of tuberculosis susceptibility genes with human macrophage gene expression profiles.
Sample Metadata Fields
No sample metadata fields
View Samples- Mus musculus
- 46 Downloadable Samples
NextSeq 500
Description
The goal of this study was to determine the role of the X-linked epigenetic mediator, O-linked N-acetylglucosamine transferase (OGT) in establishment of trophoblast-specific sex differences in gene expression and to determine if sex differences in OGT and downstream epigenetic modifications contribute to sex differences in hypothalamic gene expression and development.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part, Cell line, Treatment
View Samples- Homo sapiens
- 16 Downloadable Samples
- Affymetrix Human Genome U133A Array (hgu133a)
Description
Effect of expression of wild type KSHV RTA or the activation domain (aa608-651) deleted version of RTA in 293T cells on gene expression profiling.
Publication Title
No associated publication
Sample Metadata Fields
Cell line, Time
View Samples- Homo sapiens
- 2 Downloadable Samples
- Illumina HiSeq 2000
Description
search differential gene expression with ClC-3 knockdown
Publication Title
No associated publication
Sample Metadata Fields
No sample metadata fields
View Samples- Homo sapiens
- 24 Downloadable Samples
- Affymetrix Human Gene 1.0 ST Array (hugene10st)
Description
To identify the CAR-, PXR- and PPAR-specific genome-wide expression changes, hepatocyte cultures from six individual donors were treated with the prototypical ligands for
Publication Title
Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes.
Sample Metadata Fields
Sex, Age
View Samples- Rattus norvegicus
- 12 Downloadable Samples
- Illumina HiSeq 2500
Description
Sympathetic hyperactivity can result from cell-autonomous changes in neurons that innervate cardiovascular target tissues. Stellate ganglia are of particular interest because the majority of sympathetic neurons innervating the heart reside there. The cardiovascular risk profiles in men and women are different. Transcriptomics provides a powerful tool for identifying genomic changes that contribute to sympathetic dysfunction in disease. Here we compared the transcriptomes of healthy stellate ganglia from adult male and female WKY rats.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part, Disease, Cell line, Treatment
View Samples