This SuperSeries is composed of the SubSeries listed below.
Intersection of population variation and autoimmunity genetics in human T cell activation.
Sex, Age, Race, Subject
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.
Sex, Age, Specimen part
View SamplesGene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen). Primary cells from multiple immune lineages are isolated ex-vivo, primarily from young adult B6 male mice, and double-sorted to >99% purity. RNA is extracted from cells in a centralized manner, amplified and hybridized to Affymetrix 1.0 ST MuGene arrays. Protocols are rigorously standardized for all sorting and RNA preparation. Data is released monthly in batches of cell populations.
Transcriptomes of the B and T lineages compared by multiplatform microarray profiling.
Sex, Age
View SamplesGene expression profiling of CD4 T-Cells (CD4+CD62L+) from human peripheral blood mononuclear cells (PBMCs). PBMCs were isolated from healthy individuals from the Boston area.
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.
Sex, Age, Specimen part
View SamplesGene expression profiling of Monocytes (CD14+CD16-) from human peripheral blood mononuclear cells (PBMCs). PBMCs were isolated from healthy individuals from the Boston area.
Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes.
Sex, Specimen part
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Network pharmacology of JAK inhibitors.
Sex, Age, Specimen part, Compound
View SamplesSmall molecule inhibitors of JAK kinases have shown clinical effcacy in the treatment of certain autoimmune diseases. While these are known to block upstream JAK signalling events, their broader impact on the transcriptional footprint in immunocytes are unknown. Here we explore the effects of pan- and isoform-specific JAK blockade on the immuno-genomic network by genomic profiling.
Network pharmacology of JAK inhibitors.
Sex, Age, Specimen part, Compound
View SamplesGene-expression microarray datasets generated as part of the Immunological Genome Project (ImmGen) for samples that use a different set of amplification reagents (Ambion WT Expression Kit, not the Affymetrix GeneChip WT cDNA Synthesis and Amplification Kits).
The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells.
Sex, Age, Specimen part
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Parsing the Interferon Transcriptional Network and Its Disease Associations.
Sex, Age, Specimen part, Treatment, Time
View SamplesThis SuperSeries is composed of the SubSeries listed below.
No associated publication
Sex, Age
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