Analysis of 143 completely histologically-normal breast tissues resulted in the identification of a malignancy risk gene signature that may serve as a marker of subsequent risk of breast cancer development.
Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue.
No sample metadata fields
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Complementary strand microRNAs mediate acquisition of metastatic potential in colonic adenocarcinoma.
Sex
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BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival.
Disease stage, Cell line
View SamplesCompariosn of mRNA and miRNA profile in colon cancer
Complementary strand microRNAs mediate acquisition of metastatic potential in colonic adenocarcinoma.
Sex
View SamplesWe treated 8 human ovarian cancer cell lines with cisplatin in treatment/recovery cycles to induce in-vitro resistance to the drug. Microarrays measured gene expression at baseline and after each dose schedule (after recovery).
BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival.
Cell line
View SamplesBiologic markers of immune tolerance may facilitate tailoring of immune suppression duration after allogeneic hematopoietic cell transplantation (HCT). In a cross-sectional study, peripheral blood samples were obtained from tolerant (n=15, median 38.5 months post-HCT) and non-tolerant (n=17, median 39.5 post-HCT) HCT recipients and healthy control subjects (n=10) for analysis of immune cell subsets and differential gene expression. There were no significant differences in immune subsets across groups. We identified 281 probe sets unique to the tolerant (TOL) group and 122 for non-tolerant (non-TOL). These were enriched for process networks including NK cell cytotoxicity, antigen presentation, lymphocyte proliferation, and cell cycle and apoptosis. Differential gene expression was enriched for CD56, CD66, and CD14 human lineage-specific gene expression. Differential expression of 20 probe sets between groups was sufficient to develop a classifier with > 90% accuracy, correctly classifying 14/15 TOL cases and 15/17 non-TOL cases. These data suggest that differential gene expression can be utilized to accurately classify tolerant patients following HCT. Prospective investigation of immune tolerance biologic markers is warranted.
Tolerance associated gene expression following allogeneic hematopoietic cell transplantation.
Specimen part, Subject
View SamplesBackground. Genome-wide expression changes are associated with development of chemoresistance in patients with ovarian cancer (OVCA); the BCL2 antagonist of cell death (BAD) apoptosis pathway may play a role in clinical outcome.
BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival.
Disease stage
View SamplesEffect of NF-kB inhibition and activation on gene expression in mouse and human lung cancer cell-lines.
Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance.
Cell line
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No associated publication
Sex, Specimen part
View SamplesWe took a broad approach to identify novel STAT3 regulated genes by examining changes in the genome-wide gene expression profile by microarray, using cells expressing constitutively-activated STAT3. Using computational analysis, we were able to define the gene expression profiles of cells containing activated STAT3 and identify candidate target genes with a wide range of biological functions.
No associated publication
No sample metadata fields
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