Description

Tcl1 tg mice develop a chronic lymphocytic leukemia (CLL) -like disease. To investigate the contribution of the adhesion molecule CD44 to CLL pathophysiology, we developed a CD19Cre CD44flox/flox Tcl1 tg mouse with a B cell specific CD44 deficiency (CD44B Tcl1 tg).

Publication Title

Microenvironment-induced CD44v6 promotes early disease progression in chronic lymphocytic leukemia.

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