Low Klf4 expression reproducibly gives rise to a homogeneous population of partially reprogrammed iPSCs. Upregulation of Klf4 allows these cells to resume reprogramming, indicating that they are paused iPSCs that remain on the path towards pluripotency. Paused iPSCs with different Klf4 expression levels remain at distinct intermediate stages of reprogramming.
Manipulation of KLF4 expression generates iPSCs paused at successive stages of reprogramming.
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View SamplesAnalysis of MCF-7 cell clones lacking the E3 ubiquitin liganse CHIP.
No associated publication
Cell line, Treatment
View SamplesGene expression profiling reveals a potential role of Iso towards hepatic differentiation of hAECs.
Global Gene Expression Profiling Reveals Isorhamnetin Induces Hepatic-Lineage Specific Differentiation in Human Amniotic Epithelial Cells.
Specimen part
View SamplesGene expression profiling reveals a potential role of WOL in differentiation of CD34+ cells towards erythropoiesis
Comprehensive transcriptome analysis of erythroid differentiation potential of olive leaf in haematopoietic stem cells.
Specimen part
View SamplesGene expression profiling reveals a potential role of Verbenalin in neural induction and neuronal differentiation of hAECs.
Microarray analysis of verbenalin-treated human amniotic epithelial cells reveals therapeutic potential for Alzheimer's Disease.
Specimen part, Treatment
View SamplesThe early blood vessels of the embryo and yolk sac in mammals develop by aggregation of de novo forming angioblasts into a primitive vascular plexus, which then undergoes a complex remodeling process. Angiogenesis is also important for disease progression in the adult. However, the precise molecular mechanism of vascular development remains unclear.
Genome-wide identification of endothelial cell-enriched genes in the mouse embryo.
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View SamplesGene expression profiling reveals a potential role of TCQA in neuronal and pigment cell differentiation of hAECs.
Regulating cell fate of human amnion epithelial cells using natural compounds: an example of enhanced neural and pigment differentiation by 3,4,5-tri-O-caffeoylquinic acid.
Specimen part, Treatment, Time
View SamplesAnalysis of E14 embryonic stem cells lacking Trip12 ubiquitin ligase activity.
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Specimen part
View SamplesHomozygous disruption of Bteb2/Klf5, a homolog of Drosophila gap gene Krppel, led to increased expression of various differentiation marker genes, such as Fgf5, Cdx2, and Brachyury in mouse ES cells without compromising their ability to differentiate into all three germ layers. Upon removal of LIF, Klf5-deficient ES cells showed faster differentiation kinetics than wild-type ES cells. In contrast, overexpression of Klf5 in ES cells suppressed the transcription of differentiation marker genes, and maintained pluripotency in the absence of LIF. In order to search downstream genes of Klf5, we surveyed genes implicated in ES cell proliferation by microarray analysis
Krüppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs.
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View SamplesCD4+Foxp3+ regulatory T cells (Treg) are a subpopulation of T cells, which regulate the immune system and enhance immune tolerance after transplantation. Donor-derived Treg prevent the development of lethal acute graft and host disease (GVHD) in murine models of allogeneic hematopoietic cell transplantation. It was reported that a single treatment of the agonistic antibody to Death receptor 3 (DR3) in donor mice resulted in the expansion of donor derived Treg and prevented acute GVHD, although the precise role of DR3 signaling in GVHD has not been elucidated.
No associated publication
Specimen part
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