Background :To evaluate the impact of the duration of chronic inflammation on gene expression in skeletal muscle biopsies (MBx) from untreated children with juvenile dermatomyositis (JDM) and identify genes and biological processes associated with the disease progression, expression profiling data from 16 girls with active symptoms of JDM greater or equal to 2 months were compared with 3 girls with active symptoms less than 2 months.
Duration of chronic inflammation alters gene expression in muscle from untreated girls with juvenile dermatomyositis.
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Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.
Sex, Specimen part
View SamplesThese gene expression microarrays were performed as part of a project aiming to integrate quantitative proteomic, gene expression and epigenetic data from the childhood brain tumor medulloblastoma.
Proteomic analysis of Medulloblastoma reveals functional biology with translational potential.
Sex, Specimen part
View SamplesExpression profiling of rapidly-induced genes upon VSV infection at 4 hours post-infection in Drosophila cells
Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila.
Cell line
View SamplesTo determine the Cdk9 targets of VSV-induced genes in Drosophila cells at 4 hours post-infection
Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila.
Cell line, Treatment
View SamplesChanges in Gene exporession after 8 weeks of PrimaVie Shilajit Supplementation were measured in vastus lateralis
The Human Skeletal Muscle Transcriptome in Response to Oral Shilajit Supplementation.
Specimen part, Subject
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Histone Deacetylase 3 Is Required for Efficient T Cell Development.
Specimen part
View SamplesHdac3 is an important target of HDAC inhibitors used in the treatment of cutaneous T cell lymphoma. In order to gain an understanding of Hdac3 function in T cells,we deleted Hdac3 from early mouse thymocytes using LCK-Cre. Hdac3 deletion resulted in a loss of single positive thymocytes due to a defect in positive selection at the double positive (DP) stage of thymocyte development. To better characterize this defect, we sorted the DP1 and DP2 populations to for gene expression profiling. Overall design: Total RNA was extracted from DP1 (GFP+CD4+CD8+CD5loTCRblo) or DP2 (GFP+CD4+CD8+CD5hiTCRbint) thymocytes isolated by FACS from Hdac3+/+ or Hdac3F/F LCK-Cre+ animals. Libraries were constructed from rRNA-depleted total RNA pools to identify altered gene expression in DP populations following Hdac3 deletion.
Histone Deacetylase 3 Is Required for Efficient T Cell Development.
Specimen part, Cell line, Subject
View SamplesThe objective of the study was to compare the wound macs with corresponding macs derived from peripheral blood monocytes (MDMs). Wound site macrophage (wound macs were isolated from human subjects with chronic wounds. Matching blood monocyte derived macrophages (MDM) were obtained from same subjects. Transcriptome profiling (GeneChip, Affymetrix) was performed.The expression values of genes were normalized using global scaling approach.
Prostaglandin E₂ induces oncostatin M expression in human chronic wound macrophages through Axl receptor tyrosine kinase pathway.
Specimen part
View SamplesGata5 efficiently promotes cardiomyocyte fate from murine ESCs.By removing serum from the culture conditions, GATA4 and GATA6 are each also able to efficiently promote cardiogenesis in ESC derivatives, with some distinctions. Thus, GATA factors can function in ESC derivatives upstream of other cardiac transcription factors to direct specification of progenitors with cardiac potential.
GATA factors efficiently direct cardiac fate from embryonic stem cells.
Cell line
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