Chronic inflammation during placental malaria (PM) caused by Plasmodium falciparum is most frequent in first-time mothers and is associated with poor maternal and fetal outcomes. In the first genome wide analysis of the local human response to sequestered malaria parasites, we identified genes associated with chronic PM, then localized the corresponding proteins and immune cell subsets in placental cryosections.
Genome-wide expression analysis of placental malaria reveals features of lymphoid neogenesis during chronic infection.
No sample metadata fields
View SamplesGraft versus host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular pathways that cause this disease remains incomplete, leading to inadequate treatment strategies. To address this, we measured the gene expression profile of non-human primate (NHP) T cells during acute GVHD. In this study we specifically interrogated the transcriptional signatures of animals treated with FR104 monotherapy and FR104/Sirolimus combination therapy
Combined OX40L and mTOR blockade controls effector T cell activation while preserving T<sub>reg</sub> reconstitution after transplant.
Specimen part, Subject
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.
Specimen part, Subject
View SamplesGraft versus host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular pathways that cause this disease remains incomplete, leading to inadequate treatment strategies. To address this, we measured the gene expression profile of non-human primate (NHP) T cells during acute GVHD. This transcriptome analysis enables an unsupervised approach to the identification of targets for disease control using a model with an immune system that closely overlaps with the human and has a high degree of cross-reactivity with human antibody-based therapeutics.
Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.
Subject
View SamplesCultures of primary human airway epithelial cells (HAE cells) were exposed to an MDCK equivalent MOI of 0.01 of several swine- and human-origin influenza viruses and RNA was extracted at the 12, 16, and 24 hours post infection.
25-Hydroxycholesterol acts as an amplifier of inflammatory signaling.
Specimen part
View SamplesGraft versus host disease (GVHD) is the most common complication of hematopoietic stem cell transplant (HCT). However, our understanding of the molecular pathways that cause this disease remains incomplete, leading to inadequate treatment strategies. To address this, we measured the gene expression profile of non-human primate (NHP) T cells during acute GVHD (GSE73723). Within these profiles we discovered potentially druggable targets not previously implicated in GVHD, prominently including aurora kinase A (AURKA). In this study, we performed a planned comparison of AURKA gene expression in HCT-recipients with clinical GVHD and compared it to expression in HCT-recipients without clinical GVHD.
Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.
Specimen part, Subject
View SamplesAVICs were exposed to cyclic stretch to examine the role of mechanical stimuli on gene expression
The stretch responsive microRNA miR-148a-3p is a novel repressor of IKBKB, NF-κB signaling, and inflammatory gene expression in human aortic valve cells.
Specimen part
View SamplesTranscriptome analysis to compare parathyroid adenomas and normal parathyroid glands with the aim of identifying differentially expressed genes
No associated publication
Sex, Age, Specimen part, Disease, Race
View SamplesA QTL intercross was performed bewteen C57BL/6J and KK/HIL for albuminurea, asthma and cardiovascular related phenotypes. Several QTL were identified for most phenotypes. We performed microarray analysis from liver samples to identify genes differentially expressed between the parental strains. The results helped us narrow down the QTL and identify the candidate genes based on differential expression between the parental strains.
A major X-linked locus affects kidney function in mice.
Sex, Specimen part
View SamplesCell lines geneticially engineered to undergo conditional asymmetric self-renewal were used to identify genes whose expression is asymmetric self-renewal associated (ASRA). Non-random sister chromatid segregation occurs concordantly with asymmetric self-renewal in these cell lines.
A resource for discovering specific and universal biomarkers for distributed stem cells.
Cell line
View Samples