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SRP081182
Homo sapiens
2 Downloadable Samples
Illumina HiSeq 4000
Description
understand the funcation of fatty
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part
View Samples- Gallus gallus
- 20 Downloadable Samples
- Illumina HiSeq 2500
Description
Male broilers from two lines (n=10 per line) with different growth rate were raised at the same condition with free access to feed and drink. At day 6 and day 21, half samples of each broiler line were euthanized by cervical dislocation, and left ventricles were collected for RNA isolation. Gene expression in left ventricle was measured by RNA-seq and compared between different time points and chicken lines. The purpose of this study is to investigate gene expression change during broiler cardiac development and to compared gene expression between fast-growing modern broilers and slow-growing heritage broilers to find possible genes and pathways related to differential cardiac development and differential susceptibility to cardiac diseases between the two broiler lines.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part, Disease
View Samples- Gallus gallus
- 8 Downloadable Samples
- Illumina HiSeq 2500
Description
broilers heat stress.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part
View Samples- Sus scrofa
- 23 Downloadable Samples
Affymetrix Porcine Genome Array (porcine)
Description
This study was performed to determine the effects of dietary fat sources, i.e., beef tallow, soybean oil, olive oil and coconut oil (each 3% in feed), on the growth performance, meat quality and gene expression in growing-finishing pigs.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part
View Samples- Homo sapiens
- 2 Downloadable Samples
- Affymetrix Human Gene 2.0 ST Array (hugene20st)
Description
Inhalation of toxic chemicals, including recent e-cigarettes, often cause life-threatening lung injury. Although exposure to polyhexamethylene guanidine (PHMG)-containing humidifier disinfectant (HD) has been identified as a cause of fatal lung injury, the mechanism underlying HD-associated lung injury (HDLI) is unknown. The present study evaluated global changes in gene expression in lung tissues from patients with PHMG-induced HDLI, and compared gene expression changes in PHMG-induced rat lung tissues. Significantly different expressions in lung tissues between patients with HDLI and unaffected controls were observed. Furthermore, several fibrosis-associated overlapping genes (such as MMP2 and COL1A2) shared between humans with HDLI and rats exposed to PHMG were identified. Interactome network analysis predicted different pathways between children and adults with HDLI: the TGFβ/SMAD signaling pathway was central in adults, whereas other pathways, including integrin signaling, were associated with HDLI in children. Further interactome network analysis revealed that Rap1 and CCKR signaling pathways were significantly enriched in HDLI compared with idiopathic pulmonary fibrosis as well as their recapitulation in the lung tissues of rats exposed to PHMG. Our results suggest that MMP2-mediated different mechanisms between children and adults may be associated with PHMG-induced HDLI development, and Rap1 and CCKR pathways appear to be crucial.
Publication Title
Integrative multi-omics approach for mechanism of humidifier disinfectant-associated lung injury.
Sample Metadata Fields
Age, Specimen part
View Samples- Gallus gallus
- 7 Downloadable Samples
- Illumina HiSeq 2000
Description
The goal of this study is to obtain the transcriptomes of chicken magnum in different natural developmental stages. There are totally five stages researched in this study and they are named D1, D2, D3, D4 and L. D1 to D4 are the abbreviations of developmental stage 1 to developmental stage 4 and L means laying stage. D1 refers to the lag phase (about 7 weeks old) in which the magnum has very slight change; D2 refers to the early proliferation phase (about 13 weeks old); D3 refers to the late proliferation phase (about 16 weeks old); D4 refers to the early differentiation phase (about 17 weeks old).
Publication Title
No associated publication
Sample Metadata Fields
Age
View Samples- Gallus gallus
- 6 Downloadable Samples
- Illumina HiSeq 2500
Description
In the experiment, we took a chinese chicken with different body weights at 300 days as the research subjects. The chickens were divided into fast- and slow-growing groups (high body weight and low body weight). We selected leg muscles after slaughtering and used then for RNA-seq. Finally, we screened differentially expressed genes and the corresponding enriched pathways related to growth through a bioinformatics analysis. The results provide a theoretical foundation for revealing the molecular mechanism of the growth for chickens and improving the production performance of the Jinghai yellow chicken.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part
View Samples- Sus scrofa
- 6 Downloadable Samples
- Illumina HiSeq 2000
Description
Backfat thickness traits are strongly associated with meat quality, fattening efficiency, reproductive performance, and immunity in pigs. Fat storage and fatty acid synthesis mainly occur in adipose tissue. Therefore, we used a high-throughput massively parallel sequencing approach to identify transcriptomes in adipose tissue from three full-sibling pairs of pigs with opposite (high and low) backfat thickness phenotypes.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Age, Specimen part
View Samples SRP174379- Ovis aries
- 6 Downloadable Samples
- Illumina HiSeq 2000
Description
In order to indentify and screen the differentially expressed genes in meat sheep mammary tissues between healthy and naturally infected with clinical mastitis
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part
View Samples SRP160045- Sus scrofa
- 4 Downloadable Samples
- Illumina HiSeq 2000
Description
The regulation of lipid metabolism takes place in the principal organs as liver. In this study, we have used massive parallel high-throughput sequencing technologies to the porcine liver tissue transcriptome architecture in two pairs full-sibs Landrace pigs showing extreme phenotypes for backfat thickness of live.
Publication Title
No associated publication
Sample Metadata Fields
Sex, Specimen part
View Samples