VEGF and VEGFB Play Balancing Roles in Adipose Differentiation, Gene Expression and Function
No associated publication
Sex, Specimen part, Cell line
View Samplesgene expression study on brain and lung under Dip2a regulation to better understand the role of Dip2a gene during mice brain and lung development.
Large genomic fragment deletions and insertions in mouse using CRISPR/Cas9.
Sex, Specimen part, Cell line
View SamplesNeurobiological causes of suicide are largely unknown. Volumes and dysfunction of brain regions amygdala, hippocampus, prefrontal cortex and thalamus were reported to play a role in suicidal intention.
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Subject
View SamplesCathepsin inhibitors have been associated to induce changes in Th1/Th2 polarization; cathepsin B inhibitor CA074 has been reported to induce a Th1 polarization, whereas cathepsin L inhibitor CLIK148 has been reported to induce a Th2 polarization.
No associated publication
Specimen part, Treatment
View SamplesThe most common oncogenic mutations in multiple myeloma (MM) affect N- and K-RAS leading to constitutive activation of RAS-dependent signaling. Signal transduction via RAS, Raf and MAPK has been well described as a canonical pathway. In accordance with this assumption, we showed that the activity of the MEK/ERK module is strictly dependent on pan-Raf activity. However, inhibition of MEK/ERK has no or only minor effects on MM cell survival, whereas oncogenic Ras and pan-Raf critically contribute to survival of multiple myeloma cells. Therefore, we aimed to learn more about Raf-dependent but MEK-independent signaling effectors.
Pan-Raf co-operates with PI3K-dependent signalling and critically contributes to myeloma cell survival independently of mutated RAS.
Cell line
View SamplesAutophagy generally participates in innate immunity by elimination of intracellular pathogens. However, many of them developed successful strategies to counteract their autolysosomal digestion and lastly to exploit this catabolic cellular process.
Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210.
Specimen part
View SamplesAttention-deficit / hyperactivity disorder (ADHD) is a clinically heterogeneous childhood behavioral neurodevelopmental disorder which is highly persistent into adulthood and shows an heritability up to 80%. In previous studies, our group delineated the 9q22 region by both linkage studies and genome-wide association studies as a candidate locus for ADHD. This region harbors the DIRAS2 (MIM: 607863) gene which is coding for a Ras GTPase.
No associated publication
Specimen part, Treatment
View SamplesAPOBEC3G in human CemSS T cells acts antivirally also against negative-strand RNA viruses as found in Vero cells (Fehrholz et al., 2012, J.Gen.Virol. 93, 565-575, DOI 10.1099/vir.0.038919-0).
No associated publication
Specimen part, Cell line
View SamplesBecause most human stroke victims are elderly, studies of experimental stroke in the aged rather than the young rat model may be optimal for identifying clinically relevant cellular responses, as well for pinpointing beneficial interventions.
Transcriptomics of post-stroke angiogenesis in the aged brain.
Sex, Age, Specimen part
View SamplesMolecular effectiveness of antidepressants is a still not sufficiently understood process. The hippocampus as a brain region controlling formation of memory and learning processes as well as emotional evaluation during memory retrieval is of special interest in this reagard. We compared gene expression profiles in hippocampi of male DBA/2 mice after one month of different daily doses of the sSNRI antidepressant Venlafaxine to determine genes regulated under the chronic influence of this drug to gain insight in potential molecular changes that might reflect transformation from pathological to physiological condition. Additionally to basic research this might provide new targets of pharmacological interventions for depression.
No associated publication
Sex
View Samples